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Metformin lessens the amount of glucose (sugar) in a triple action method. This consists of:
1. Lowering the level of glucose produced in the liver
2. Lowering the level of glucose absorbed from food by means of your stomach
3. Developing the efficacy of insulin in the body in lowering glucose that exists in the blood.
Diabetes types I and II are becoming increasingly common with type II form being most prevalent in the elderly. Diabetes is a metabolic disorder whereby the pancreas is incapable of producing satisfactory amounts of insulin to prevent hyperglycemia. This is then followed by diabetic symptoms of blurry vision, weight loss, excessive thirst and continuous fluid drinking amongst others.
By improving how the body handles insulin, Metforminhelps lower blood sugar levels. This is achieved through preventing the liver from producing excess glucose by making muscle and fat cells increasingly sensitive to insulin that is available.
Not only does Metformin reduce glucose the long term cause of diabetes, but it can also reduce blood cholesterol and triglyceride levels and still prevent weight gain unlike other blood-glucose lowering drugs which are unable to do. High levels of overweight, cholesterol and triglyceride all increase the risk of forming heart disease, which is the top cause of death in those suffering from Type II diabetes. Moreover Metformin prevents hypoglycemia (low blood glucose) when it is the sole diabetic medicine taken.
The performance of Metformin is different to other anti-diabetic drugs like sulfonylureas (e.g., Glyburide, Diabinase, Micronase, etc). Sulfonylureas perform by raising the output of insulin from the pancreas. After some time this can result in the failure of the pancreas thus changing a Type II diabetic who is non-insulin dependent into a Type I who is insulin dependent.
Metformin performs by raising the sensitivity of the hypothalamus and peripheral tissues to the effect of insulin. As a result it is able to revitalize this response returning glucose and insulin effects to physiologically younger levels. Those who are Type I insulin dependent can often radically lower their insulin dose thus easily maintain stabilized blood glucose levels.
Metforminperforms in a more physiologic approach than sulfonylureas or even exogensously administered insulin itself. As a result Metformin does not cause hypoglycemia which is often an outcome of insulin or the sulfonylureas.